Oxidative stress links periodontal inflammation and renal function

Aims Patients with chronic kidney disease (CKD) are also susceptible to periodontitis. The causal link between periodontitis and CKD may be mediated via systemic inflammation/oxidative stress. Using structural equation modelling (SEM), this cross-sectional study aimed explore the relationship periodontal inflammation (PI) renal function. Materials methods Baseline data on 770 patients stage 3–5 (pre-dialysis) from an ongoing cohort were used. Detailed, bioclinical PI function, as well potential confounders mediators of two, collected. SEMs increasing complexity created test assumption that affects function vice versa. Results Structural confirmed causally linked, by oxidative magnitude effect was such a 10% increase in resulted 3.0% decrease 25% PI. Conclusions Periodontal represents occult source stress CKD. Further clinical studies needed confirm whether therapy, non-pharmacological approach reducing inflammatory/oxidative burden, can improve outcomes